Quality Requirement

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STEM ESOP HA PRODUCTION QUALITY

GENERAL SUMMARY

FHI has been ISO 9001 and EN 46001 certified respectively by AFAQ and G'MED

  • Full production traceability with 30 years data records
  • Regular inspection instrument calibration by specialised firms
  • Personnel trained for special processes, such as cleaning (approval given by APAVE)
  • ESOP HA is FDA approved

 

  • Dimensional inspection in an air conditioned metrology lab.
  • Unit 12/14 cones check by electro-pneumatic system measuring diameters and cone angle
  • Microfiletage inspection of the cone with a profile projector
  • Class 100 (ASTM) clean room packaging at blister pack station
  • Cleaning and rinsing using demineralised water, filtered at .1 microns, treated with an ultra violet gun

METAPHYSIS

Systematic inspection

(unit)

Statistic inspection

(99 % reliability grid)

Parameter Inspection

MATERIAL

TA6V ELI

ISO and ASTM (USA standard) compliance documentary checks

Material sampling and analysis by approved lab.

.

.

Chemical composition check

Chemical composition check

Mechanical traction and strech at break resistance check

Mechanical traction and strech at break resistance check

Grain size test

Grain size test

FORGE

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Compliance forge parameters (temperature, thermal treatments, strike power)

Geometric check by drawing

.

 

Grain size test after forge and thermal treatment

TURNING

Inter

First part setting dimensional test

.

 

.

 

exter

Full dimensional and three dimension machine geometry test, 2 micron accuracy

1 part out of 10 in process check by production operator using a micrometer, calliper, gauge

Digital control machine programmes

Unit cones check (diameter and angle) by an electro-pneumatic system

Random daily check by quality control with its own measuring instruments (possible detection of calibration error in production's control instrument)

.

 

Microfiletage inspection of the cone with a profile projector

POLISHING and ANODIZATION

.

 

.

 

Visual inspection according to standards

Pressure, tie and abrasion load quality parameter inspection

HAP

.

 

Powder batch check according to ISO standard

Thickness inspection

Pressure, plasma speed, temperature inspection

Heavy metal %

Crystalline phase % control on deposit

Crystalline phase %

Porosity check

Tear resistance

Unit visual inspection

Coating peak-to-valley

CLEANING

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Part bacterial contamination check

Periodical cleaning water inspection

Chemical contamination check (for NA, Nitrates, hydrocarbures)

Rinsing water ultra violet treatment efficiency check

GAMMA STERILISING

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.

 

Initial contamination inspection according to pharmacopoeia

Parameter irradiation dose check

Process validated according to ISO standard

Part sterilisation check

Blister pack stripping

Blister pack sealing check

Shell and tyveck thickness inspection

LABELLING

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Production quantity check at each step in order to identify possible mixes

Unit weighing inspection (for size error)

.

 

DIAPHYSIS

Systematic inspection

(unit)

Statistic inspection

(99 % reliability grid)

Parameter inspection

MATERIAL

TA6V ELI

ISO and ASTM (USA standard) compliance documentary checks

Material sampling and analysis by approved lab.

.

 

Chemical composition check

Chemical composition check

Mechanical traction and strech at break resistance check

Mechanical traction and strech at break resistance check

Grain size test

Grain size test

TURNING

Inter

First part setting dimensional test

.

 

.

 

exter

Full dimensional and three dimension machine geometry test, 2 micron accuracy

 

1 part out of 10 in process check by production operator using a micrometer, calliper, gauge

Digital control machine programmes

 

Random daily check by quality control with its own measuring instruments (possible detection of calibration error in production's control instrument)

POLISHING and ANODIZATION

.

 

.

 

Visual inspection according to standardised sets

Abrasive filler quality time and pressure parmeter check

CLEANING

.

 

.

 

Part bacterial pollution check

Regular cleaning water check

Chemical contamination check (for NA, Nitrates, hydrocarbures)

Rinsing water ultraviolet treatment efficiency check

GAMMA STERILISING

.

 

.

 

Initial contamination inspection according to pharmacopoeia

Parameter irradiation dose check

 

Process validated according to ISO standard

 

Part sterilisation check

Blister pack stripping

Blister pack sealing check

Shell and tyveck thickness inspection

LABELLING

.

 

Production quantity check at each step in order to identify possible mixes

Unit weighing inspection (for size error)

.

 


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